Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation Research Published on 2022-06-082022-10-05 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation airways binding pocket canonical cleaved effort explain feature half-maximal inhibitory concentration host cell identify implicated Infection inhibit inhibitor mechanism membrane fusion nonspecific pathogenesis of SARS-CoV-2 protease Protease inhibitor Protein proteolytic activity provide S1/S2 cleavage site SARS-CoV-2 SARS-CoV-2 S protein serine 2 specificity spike Structure the SARS-CoV-2 TMPRSS2 TMPRSS2 protease viral entry X-ray [DOI] 10.1038/s41589-022-01059-7 [Article Type] Research
ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusionADAM10 및 ADAM17은 SARS-CoV-2 세포 진입 및 스파이크 단백질 매개 폐 세포 융합을 촉진합니다Article Published on 2022-06-072022-09-11 Journal: EMBO Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A549 ADAM10 ADAM17 Alpha antiviral drug apratastat Beta causative agent Cell Cell fusion cleave contribute contributing to COVID-19 COVID-19 pathogenesis COVID-19 pathology DPC-333 ectodomain ectodomain shedding expressed facilitator hallmark Host host cell host cell factor host cell factors human lung human lung cell identify impair in vitro Infection inhibitor lung cell omicron Pathogenesis pathology priming promote protease Proteases reduce required SARS-CoV-2 SARS-CoV-2 cell SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 variants Spike protein syncytia formation syncytia formation. target the SARS-CoV-2 TMPRSS2 TMPRSS2 protease variants of concern viral entry [DOI] 10.15252/embr.202154305 PMC 바로가기 [Article Type] Article
Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label StudyResearch Article Published on 2022-01-292022-10-29 Journal: Interdisciplinary Perspectives on Infectious Diseases [Category] COVID-19, [키워드] adverse events assigned Asymptomatic bromhexine Bromhexine hydrochloride cells Contact Control control group controls COVID-19 Endpoint enrolled Enrollment first positive hydrochloride Infection involved management Nasopharyngeal swab not differ Open-label participant Patient PCR PCR test penetration per day polymerase chain positive positive swab primary endpoint prophylactic treatment Prophylaxis Randomized reduced respiratory infection Result risk reduction SARS-CoV-2 SARS-COV-2 infection secondary significantly suggested symptomatic TMPRSS2 protease Treatment treatment group with COVID-19 [DOI] 10.1155/2022/4693121 PMC 바로가기 [Article Type] Research Article
TMPRSS2 promotes SARS-CoV-2 evasion from NCOA7-mediated restrictionTMPRSS2는 NCOA7 매개 제한으로부터 SARS-CoV-2 회피를 촉진합니다Research Article Published on 2021-11-222022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 유전자 메커니즘, [키워드] acquisition Activation Antiviral Antiviral effect antiviral effects ATPase biological significance Cell cell surface characterized cleavage coactivator concomitant use consequence coronavirus Critical cytoplasmic dysregulation ectopic expression Effect effector endocytic Endosomal acidification epithelial cells evade furin furin cleavage furin cleavage site gene knockout HCoV HCoV-229E HCoV-NL63 highly pathogenic Host immune response host immune responses IFN IFN treatment IFNs immune responses Inborn errors Infection infections inhibit inhibit SARS-CoV-2 inhibited inhibitor innate immune response innate immune responses interact interferon interferons ISG ISGs isoform lentivirus less Lung epithelial cells lysosomal protease mechanism MERS MERS-CoV NCOA7 NL63 nuclear nuclear receptor option overexpression Particle pathway patients with COVID-19 plasma membrane polybasic promote protease Protein pseudotyped Pseudotyped viruses receptor removal repertoire Research RNA robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike seasonal severe COVID-19 spike Spike protein Support the interferon TMPRSS TMPRSS2 TMPRSS2 protease Trigger vacuolar Vesicle Viral viral spike protein virus virus virus entry virus infection virus infections viruses [DOI] 10.1371/journal.ppat.1009820 PMC 바로가기 [Article Type] Research Article
The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitroSARS-COV-2 스파이크 단백질과 ACE2 사이의 상호 작용에 대한 치약 및 구강 세척 성분의 억제 효과 및 시험 관내 TMPRSS2의 프로테아제 활성.Research Article Published on 2021-09-172022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] ACE2 angiotensin angiotensin-converting enzyme 2 binding cleaved copper copper gluconate docking evaluated expressed help Host host cell host cells in vitro ingredient inhibitory effect Inhibitory effects Interaction mouthwashe mouthwashes mucosa oral cavity Prevent protease Protease activity SARS-CoV-2 SARS-COV-2 infection Serine serine 2 sodium sodium dodecyl sulfate sodium N-lauroylsarcosinate Spike protein suggested sulfate the SARS-CoV-2 TMPRSS2 TMPRSS2 protease tongue tranexamic acid transmembrane transmembrane protease serine 2 Viral viral spike protein [DOI] 10.1371/journal.pone.0257705 PMC 바로가기 [Article Type] Research Article
Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in researchArticle Published on 2021-07-242022-10-31 Journal: Journal of lung, pulmonary & respiratory research [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome angiotensin Angiotensin converting enzyme-2 angiotensin converting enzyme-2 (ACE-2) binding caused coronavirus COVID-19 disease Epidemic facilitate host cell Like Lung injury membrane fusion novel SARS-CoV-2 virus proteolytic cleavage receptor renin angiotensin system Research SARS-CoV SARS-CoV-2 shown Spike protein the SARS-CoV-2 TMPRSS2 protease virus PMC 바로가기 [Article Type] Article
Expression of SARS-CoV-2 Entry Factors in Human Alveolar Type II Cells in Aging and EmphysemaArticle Published on 2021-07-062022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 aging alveolar type II cells ATII cause CD209L Cell described Diffuse alveolar damage disease emphysema expression facilitate Factor Host Human Infection lung transplant Lungs mRNA level Patient patients proliferate protein expression receptor Regulation RT-PCR SARS-CoV-2 SARS-CoV-2 entry factor SARS-COV-2 infection significantly increased smoker Smokers smoking Stress TMPRSS2 TMPRSS2 protease Type upregulation viral entry virus infection western blotting [DOI] 10.3390/biomedicines9070779 PMC 바로가기 [Article Type] Article
Comparative analyses of ACE2 and TMPRSS2 gene: Implications for the risk to which vertebrate animals are susceptible to SARS‐CoV‐2Research Article Published on 2021-05-192022-11-01 Journal: Journal of medical virology [Category] COVID-19, SARS, [키워드] 3D structure ACE2 acute respiratory syndrome Amino acid Analysis analysis binding calculated Comparative Contact coronavirus coronavirus disease enzyme Fisher exact test Genome human ACE2 humans hydrophobic Infection lack less livestock occur Outbreaks Probability receptor residue risk SARS‐CoV‐2 SARS‐CoV‐2 searched selected Seven susceptibility susceptible TMPRSS2 TMPRSS2 protease Transmission Vertebrate vertebrates virus [DOI] 10.1002/jmv.27073 PMC 바로가기 [Article Type] Research Article
Scutellaria barbata D. Don Inhibits the Main Proteases (M pro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) InfectionScutellaria barbata D. Don은 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염의 주요 프로테아제(M pro 및 TMPRSS2)를 억제합니다Article Published on 2021-05-022022-08-31 Journal: Viruses [Category] SARS, 치료제, [키워드] Scutellaria barbata activities acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis Analysis applied approach Calu3 cellular component Compound compounds coronavirus coronavirus 2 creating derivative determine effective Effectiveness enzyme activities enzyme activity expressing followed by function identify Infection infection assays inhibited inhibiting inhibitory activity inhibitory effect Inhibitory effects involved literature review M pro mechanism pandemic Prevent protease Proteases pseudoparticle Replication respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) TMPRSS2 TMPRSS2 protease Treatment VeroE6 cell VeroE6 cells Viral viral pseudoparticles were assessed [DOI] 10.3390/v13050826 PMC 바로가기 [Article Type] Article
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection알파-1 항트립신은 TMPRSS2 프로테아제 활성과 SARS-CoV-2 감염을 억제합니다Article Published on 2021-03-192022-09-10 Journal: Nature Communications [Category] SARS, 신약개발, 진단, 치료제, [키워드] acute phase airway epithelium Antiviral bind Bronchoalveolar lavage cell line cell lines circulating Concentration COVID-19 cultures Defense drug Factor fraction human airway epithelial identify infect inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 innate immune knowledge membrane fusion Novel coronavirus physiological primary cell primary cells Protein respiratory respiratory pathogen respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 spike protein screened Serine serine protease serine protease inhibitor serine protease TMPRSS2 Spike protein suppresse the SARS-CoV-2 therapy TMPRSS2 TMPRSS2 protease Translational research Viral viral replication [DOI] 10.1038/s41467-021-21972-0 PMC 바로가기 [Article Type] Article